Johnny Depp - John Dillinger

Giovanni Ribisi - Alvin Karpis

Billy Crudup - J. Edgar Hoover

Marion Cotillard - Billie Frechette

Emilie de Ravin - Anna Patzke

Channing Tatum - Pretty Boy Floyd

Leelee Sobieski - Polly Hamilton

Domenick Lombardozzi - Gilbert Catena

Stephen Lang - Charles Winstead

Carey Mulligan - Carol Slayman

James Russo - Walter Dietrich

David Wenham - Harry 'Pete' Pierpont

Christian Stolte - Charles Makley

Jason Clarke - 'Red' Hamilton

John Judd - Turnkey

Stephen Dorff - Homer Van Meter

Michael Vieau - Ed Shouse

John Kishline - Guard Dainard

Wesley Walker - Jim Leslie

John Scherp - Earl Adams

Elena Kenney - Viola Norris

William Nero Jr. - Toddler on Farm

Don Frye - Clarence Hurt

Branka Katić - Anna Sage

Stephen Graham - Baby Face Nelson

Michael Sassone - Farmer

Rory Cochrane - Agent Carter Baum

Madison Dirks - Agent Warren Barton

Casey Siemaszko - Harry Berman

John Michael Bolger - Martin Zarkovich

Peter DeFaria - Grover Weyland

Jonathan Macchi - Tellers

Jeff Shannon - Angry Cop

Robyn LeAnn Scott - Ella Natasky

Bill Camp - Frank Nitti

John Ortiz - Phil D'Andrea

Richard Short - Agent Sam Cowley

Randy Ryan - Agent Julius Rice

Shawn Hatosy - Agent John Madala

Kurt Naebig - Agent William Rorer

John Hoogenakker - Agent Hugh Clegg

Adam Mucci - Agent Harold Reinecke

Rebecca Spence - Doris Rogers

Diana Krall - Torch Singer

Shanyn Leigh - Helen Gillis

Lili Taylor - Sheriff Lillian Holley

Stephen Spencer - Emil Wanatka

Rick Uecker - Edward Saager